Health Citizens – European Research Institute

Tag: Depression

  • The Psychotic Impact of Helicobacter pylori Gastritis and Functional Dyspepsia on Depression: A Systematic Review

    The Psychotic Impact of Helicobacter pylori Gastritis and Functional Dyspepsia on Depression: A Systematic Review

    The clinical practice of adding antidepressant drugs to the therapy for the eradication of Helicobacter pylori, in addition to the standard drug regimen, has been widely considered in recent years but its specific role in this treatment is still unclear.

    In this systematic review researchers tried to establish if there is an association between H. pylori gastritis and depression and to further analyze the therapeutic effect of antidepressants on symptomatic relief in gastritis. For that, they analyzed randomized clinical trials, cross-sectional and prospective studies, and review articles that examined H. pylori infection, depression, functional dyspepsia, and antidepressant treatment. They focused especially on patients whose digestive symptoms did not improve even after successful H. pylori eradication.

    Across the studies, a clear pattern emerged: patients with ongoing functional dyspepsia after H. pylori treatment often improved when they were given antidepressants, even when standard eradication therapy alone had not worked. However, the authors highlight that more research is needed before this approach becomes routine medical practice.

    Learn more about this review here: https://doi.org/10.7759/cureus.5956

    Reference

    Al Quraan A M, Beriwal N, Sangay P, et al. (October 21, 2019) The Psychotic Impact of Helicobacter pylori Gastritis and Functional Dyspepsia on Depression: A Systematic Review. Cureus 11(10)

  • Psychological effects of Helicobacter pylori-associated atrophic gastritis in patients under 50 years: A cross-sectional study

    Psychological effects of Helicobacter pylori-associated atrophic gastritis in patients under 50 years: A cross-sectional study

    A cross-sectional, observational study involving 975 Japanese individuals who underwent a health checkup, has found that people with atrophic gastritis had a significantly higher risk of experiencing psychological distress or depressed mood.

    Interestingly, the risk was higher in females under 50 years old, regardless of H. pylori infection status.

    Although the mechanism remains to be elucidated, the researchers suggest there is a possibility that nutritional status, neuroendocrinologic factors, and/or socioeconomic factors are involved. However, further studies are necessary to reveal the precise underlying mechanisms.

    Learn more about this study here: https://doi.org/10.1111/hel.12445

    Reference

    Takeoka A, Tayama J, Kobayashi M, et al. Psychological effects of Helicobacter pylori-associated atrophic gastritis in patients under 50 years: A cross-sectional study. Helicobacter. 2017; 22:e12445

  • Correlation between social factors and anxiety-depression in function dyspepsia: do relationships exist?

    Correlation between social factors and anxiety-depression in function dyspepsia: do relationships exist?

    A research study conducted on the Chinese population in 2014 aimed at evaluating the prevalence and the social factors linked to anxiety and depression in patients with functional dyspepsia (FD). This study included 907 patients with FD who attended a gastroenterology service.

    Despite being a hospital-based study, results showed that patients with functional dyspepsia had higher anxiety and depression scores when compared to data from the general population. They also found that a higher prevalence of A/D was observed in women, older individuals, those with lower socioeconomic status (lower wages, lower education levels), and those with more stressful jobs, making these aspects risk factors for the development of A/D. Interestingly, they found no differences in relation to family history.

    Learn more about this study here: https://doi.org/10.5114/pg.2014.47897

    Reference

    Huang, Z., Yang, X., Lan, L., Liu, T., Liu, C., & Li, J. et al. (2014). Correlation between social factors and anxiety-depression in function dyspepsia: do relationships exist?. Gastroenterology Review/Przegląd Gastroenterologiczny, 9(6), 348-353.